Senior Scientist II Cell Therapy Discovery

Summary Of The Role

You will own key assays and workflows for CAR design, T-cell engineering, and in vitro functional characterization.

You will partner with project teams to enable data-driven decisions that advance programs from discovery toward translation.

You will help shape study plans, and ensure timely delivery of milestones across functions.

Role & Responsibilities

• Study Design and Execution: Design and run in vitro studies for CAR T candidates; design constructs and characterize engineered cell therapies; develop, execute, and optimize functional assays.
• Data analysis and reporting: Analysis data, generate figures, and prepare reports and slide decks, present results and propose next experiment steps.
• Quality and compliance: Ensure adherence to required training and maintain accurate, complete experimental records.
• Cross-functional collaboration: Align with Pharmacology & Toxicology, CMC, translational science and clinical teams to advance project.
• Team and communication: Clear scientific writing and presentation, mentor colleagues and foster a productive, well-organized lab environment
• Problem-Solving: Track record of trouble shooting models, optimizing protocols, and meeting timelines in a dynamic environment.
  
  

• Primary Cell Culture: Proficient in human primary cell isolation, culture, activation, and maintenance.
• Prepare lentiviral vectors and perform transduction; optimize MOI to maximize transduction efficiency; assess vector copy number and integration characteristics; conduct electroporation-based gene edits.
• Flow cytometry: Proficient in panel design, compensation, and gating.
• Functional assays: target killing (luciferase/impedance), cytokines, proliferation/persistence, serial-kill or rechallenge assays; antigen density titration and specificity testing.
• Molecular methods: PCR/qPCR, plasmid prep; amplicon NGS prep for edit verification and transgene integrity.
• Data & Tools: Proficiency with ELN, FlowJo, Snapgene, GraphPad; understanding of assay acceptance criteria and basic statistics.
• Compliance: Practice BSL 2 biosafety, uphold animal ethics (IACUC), maintain awareness of research GxP, and ensure data integrity.
  
  

• Program Advancement: Progress CAR T candidates from lead optimization to preclinical packages; support method transfer and qualification with Process Development.
• Advanced Modalities: Experience with armored CARs, logic gated CARs.