In Vivo Scientist Oncology Immunology

Primary Responsibilities

• Design and execute preclinical in vivo studies in collaboration with discovery and data scientists, develop timelines and action plans to meet company goals.
• Choose appropriate in vivo models and develop protocols with relevant endpoints for evaluating the mechanism of action, efficacy, and safety of therapeutic candidates.
• Perform hands-on in vivo experiments, including orthotopic tumor cell implantation, IV, IP and SC injections, in vivo imaging, and animal welfare monitoring.
• Perform biological sample collection and processing, MACS/FACS cell sorting, immune cell profiling using multicolor flow cytometry, immunogenicity testing using ELISA and ELISPOT, and cell-based functional assays.
• Generate, document, analyze and interpret experimental data to support critical decisions.
• Manage external laboratories and partners.
  

• PhD in Life Sciences with specialization in oncology or immunology.
• At least 3 years of hands-on experience working with murine tumor models in an
• industry and/or academic setting.
• Demonstrated independent ability to design, execute and interpret experimental data.
• Demonstrated experience in in vivo procedures, such as rodent surgery and IV dosing.
• Experience with tissue handling and processing, cell sorting, multi-color flow cytometry and cytokine profiling, experience with IHC and ISH is a plus
• Proficiency in mammalian cell and tissue culture.
• Detail-oriented, with strong organizational and record-keeping skills.
• Excellent communication skills and ability to collaborate effectively in a cross-functional team.
• Experience working in a GLP or regulatory-compliant environment is a plus.