Research Officer Anti-viral Therapeutics Lab A*STAR ID Labs

Job Summary

A*STAR Infectious Diseases Labs (A*STAR IDL) is seeking for Research Officers to join us in our mission to be a leading centre of infectious diseases research. A*STAR IDL aims to develop a cohesive A*STAR response to drive and deliver translational infectious diseases research to better health and economic outcomes.

The laboratory headed by Dr. Marco Vignuzzi is leading cutting edge virology and antiviral and vaccine therapies. As part of the Singapore Therapeutics Development Review (STDR) program, the lab is advancing translational development of innovative antiviral strategies, including engineered defective viral genomes (DVGs), toward clinical application. We are seeking a fast learner who can participate in multiple projects in the lab. This role is a 1 year contract.

Job Description

• Perform virological assays in cell culture for a wide variety of RNA pathogens, including influenza viruses relevant to ongoing translational antiviral development projects under the STDR program
• Work with and develop mouse models to evaluate antiviral strategies and support translational therapeutic development
• Conduct laboratory experiments in vaccine/drug testing and perform data analysis for industry/research collaboration projects including projects related to the STDR therapeutic development pipeline, supporting the development of engineered defective viral genomes (DVGs) as antiviral therapeutics. This includes evaluating DVG interference with influenza virus replication in cell culture, optimizing DVG-to-wild-type ratios, assessing antiviral activity and innate immune responses, and validating therapeutic efficacy in animal models of influenza infection.
• Perform meticulous recordkeeping and able to draft delivery report to industrial partners, and contribute to documentation required for translational development programs such as STDR
• Oversee daily laboratory activities and help manage the lab’s routine admin duties
• Help new students and postdocs settle into the lab, transfer techniques to them, and participate in their research
• Ensure safe technical practices and procedures
  
  

• Qualification & Field of Study: Bachelor Degree in Biomedical Sciences, Biochemistry, Life Sciences, Biological Sciences, Infectious Diseases, Microbiology, Immunology, or related field
• Min. Years of Experience: 2 or more years of solid experimental experience, you must know how to work in molecular biology and in cell culture
  
  

• Experience with BSL-2 pathogens, and cell culture will be an asset
• General lab skills in molecular biology (cloning, PCR, RNA and DNA methods)
• Highly motivated and able to work independently and multitask
• Team player with good interpersonal skills
• Good spoken and written communication skills
• A strong desire to constantly learn and acquire new skills
• Singaporeans and Singapore PRs preferred