Analytical Chemist II

Overview

Business Title: Analytical Chemist II - Oligonucleotides

Position Title: Analyst II

Division: Consumer Products Services

Entity: Consumer Products Services/ATL

Location: Indianapolis, IN

Reports to: Manager

FLSA: Non-exempt

Hours Worked: Typically, Monday through Friday, forty-hours per week. However, must be flexible to meet the needs of the department and complete other projects as assigned.

Position Summary

The Analytical Chemist II is responsible for supporting oligonucleotide analysis portfolio and delivering analytical quality management. Analytical instruments including AKTA, LC-MS, HPLC/UPLC, LTQ, QDA, CAD, Circular Dichroism, Karl Fischer titration, UV-Vis/Fluorescence spectrophotometer, TFF, thermal cycler, Nanodrop, SoloVPE along with automation integration systems will be used on a routine basis.

Duties And Responsibilities

It is everyone’s responsibility to live out our Values and Absolutes by Shaping a World of Trust while ensuring responsible progress.

• Perform precise and accurate sample preparation, including weighing, diluting, extraction and purifying samples for various analytical techniques.
• Develop, validate and document standard operating procedures for sample handling, ensuring consistency and repeatability in all preparation activities.
• Maintain detailed records and logs of all sample preparation steps, calculations and observations, supporting data integrity and traceability
• Collect, record and organize experimental data, conduct basic analyses to interpret results and support ongoing laboratory research
• Use of general laboratory equipment including but not limited to pipettors, centrifuges, incubators, biological safety cabinets and balances
• Perform RNA Sample preparation and gel electrophoresis
• Follow instruction and perform instrumental analysis on instruments including but not limited to AKTA, LC-MS, HPLC/UPLC, LTQ, QDA, CAD, Circular Dichroism, Karl Fischer titration, UV-vis/ Fluorescence spectrophotometers, thermal cycler, Nanodrop, SoloVPE instruments, etc. Provide basic troubleshooting to mentioned instrument.
• Instrument maintenance - MS and LC (pressure, column, etc) and troubleshooting LC/MS issues as they arise
• Work closely with members of the RNAi chemistry team to understand and validate requirements for oligonucleotide analytical control.
• Hands-on and independent lab experience with concentration calculation and unit conversion, buffer preparation, solution preparation, separation, quantification of DNA/RNA, oligonucleotides, etc.
• Software includes instrument-specific for capturing and analyzing data, Microsoft Office (Word, Excel, PowerPoint, Outlook, Teams/SharePoint, GraphPad Prism, Spotfire, etc), LIMS, electronic laboratory notebooks, etc.
• Detailed record keeping of daily experiments in ELNs
• General lab maintenance and Inventory management
• Follow the guidelines set forth with clients and Company Quality, Health, Safety, Security and Environmental policies and procedures.
• Comply with clients’ and Company management systems in accordance with appropriate regulatory agencies.
• Perform other essential tasks projects and responsibilities as required.
• Other duties as defined by the Manager, department needs and workload
  
  

Skills & Proficiencies

• Experience, troubleshooting, and optimizing synthetic protocols on various synthesizers
• Strong laboratory skills and experience with analytical instrumentation such as AKTA, Agilent LC-MS and UPLC, Vanquish LTQ, Water’s QDA, etc.
• Experience in developing new chromatographic methods (IEX/RP-HPLC, SPE, LC-MS).
• Strong organizational skills and ability to prepare written technical reports
• Strong oral communication skills in presenting facts and recommendations
• Confident, execution-focused, and team oriented with a desire to thrive in a fast-paced growing environment
• Written and verbal communication skills including the ability to communicate effectively in a group setting, with colleagues and clients
• Ability to perform multiple tasks
• Ability to organize and prioritize workload to meet or exceed deadlines
• Individual and Team work ethic
• Proficiency with Windows, Word & Excel
• Attention to detail
• Positive attitude, self-motivated, high level of engagement
• Champions and adheres to company values including team engagement
  
  

Education And Experience

• Degree requirement: Bachelors Degree in Chemistry, Biochemistry, or closely related field
• One (1) year of experience with oligonucleotide chemistry helpful
• An equivalent combination of education and experience may be accepted in lieu of above
  
  

Compensation Range: $28.00-$31.00 per hour (e.g., the job posting is not necessarily reflective of actual compensation that may be earned, and actual compensation is subject to variation due to such factors as location, education, experience, and skillset).

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