Job Description
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Division
Piramal Pharma Solutions
Piramal Pharma Solutions is a contract development and manufacturing organization (CDMO), offering end-to-end development and manufacturing solutions across the drug life cycle. We serve our clients through a globally integrated network of facilities in North America, Europe and Asia.
This enables us to offer a comprehensive range of services including Drug Discovery Solutions, Process & Pharmaceutical Development services, Clinical Trial Supplies, Commercial supply of APIs and Finished dosage forms. We also offer specialized services like development and manufacture of Highly Potent APIs and Antibody Drug Conjugation.
Our capability as an integrated service provider & experience with various technologies enables us to serve Innovator and Generic companies worldwide.
For more details, please visit : www.piramalpharmasolutions.com
Job Title
Senior Research Scientist
Job Description
Perform reverse phase preparative HPLC purification of APIs, intermediates, impurities, degradants, metabolites, and synthetic target compounds.
Develop and optimize purification methods using C18, C8, Phenyl, Biphenyl, and specialty stationary phases.
Execute preparative purifications ranging from milligram to multi-gram scale.
Design and implement purification strategies for challenging compounds with poor solubility, low stability, or complex impurity profiles.
Maximize purity, recovery, and productivity while maintaining project timelines.
Method Development and Scale-Up
- Transfer analytical HPLC/UPLC methods to preparative scale.
- Optimize mobile phase composition, pH, buffers, gradients, flow rates, and loading conditions.
- Conduct loading studies and purification scale-up activities.
- Improve chromatographic resolution and recovery through systematic method optimization.
- Operate and maintain preparative HPLC systems, fraction collectors, and associated software.
- Work with systems such as Waters, Agilent, Shimadzu, Gilson, Biotage, or equivalent preparative chromatography platforms.
- Perform routine troubleshooting of chromatographic systems and columns.
- Maintain instrument utilization, calibration, and documentation records.
- Analyze collected fractions using analytical HPLC/UPLC, LC-MS, and NMR techniques.
- Interpret chromatographic and spectroscopic data to confirm compound identity and purity.
- Support impurity identification and structural characterization activities.
- Generate purification reports and technical summaries.
- Support pharmaceutical R&D, process development, impurity isolation, forced degradation, and reference standard projects.
- Collaborate with synthetic chemistry, analytical, formulation, and regulatory teams.
- Prioritize multiple projects and ensure timely delivery of purified compounds.
- Participate in client discussions and provide technical recommendations.
Job Details
| Role Level: | Not Applicable | Work Type: | Full-Time |
|---|---|---|---|
| Country: | India | City: | Ahmedabad ,Gujarat |
| Company Website: | https://www.piramalpharma.com/ | Job Function: | Clinical & Lab Research |
| Company Industry/ Sector: |
Pharmaceutical Manufacturing | ||
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